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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MC4R All Species: 5.45
Human Site: Y21 Identified Species: 13.33
UniProt: P32245 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P32245 NP_005903.2 332 36943 Y21 H L W N R S S Y R L H S N A S
Chimpanzee Pan troglodytes Q9TT23 325 36628 L21 L N A T E G N L S G P N V K N
Rhesus Macaque Macaca mulatta Q864J4 317 34745 T21 L N S T P T A T P H L G L A A
Dog Lupus familis XP_541099 632 70219 N320 H L L F L D L N S N A T E G N
Cat Felis silvestris
Mouse Mus musculus P56450 332 36970 Y21 H L W N R S S Y G L H S N A S
Rat Rattus norvegicus P70596 332 36868 H21 H L W N R S S H G L H G N A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505445 334 36107 L22 F W N H S Q G L A G T A P E A
Chicken Gallus gallus NP_001026685 331 36978 G21 H F W N Q S N G L H R G A S E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_775385 326 36403 L21 R N H S Q G A L P V G K P S H
Tiger Blowfish Takifugu rubipres NP_001027732 322 35956 E21 S N G S Q T P E T D F P N E E
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 61.7 47.8 35.9 N.A. 93.6 93.3 N.A. 82.3 87 N.A. 69.8 66.5 N.A. N.A. N.A. N.A.
Protein Similarity: 100 75.3 64.4 44.1 N.A. 97.2 96.9 N.A. 87.7 91.5 N.A. 81.3 79.2 N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 6.6 13.3 N.A. 93.3 80 N.A. 0 26.6 N.A. 0 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 26.6 26.6 N.A. 93.3 86.6 N.A. 20 46.6 N.A. 33.3 26.6 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 20 0 10 0 10 10 10 40 20 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 10 0 0 0 10 0 0 0 0 0 % D
% Glu: 0 0 0 0 10 0 0 10 0 0 0 0 10 20 20 % E
% Phe: 10 10 0 10 0 0 0 0 0 0 10 0 0 0 0 % F
% Gly: 0 0 10 0 0 20 10 10 20 20 10 30 0 10 0 % G
% His: 50 0 10 10 0 0 0 10 0 20 30 0 0 0 10 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 10 0 10 0 % K
% Leu: 20 40 10 0 10 0 10 30 10 30 10 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 40 10 40 0 0 20 10 0 10 0 10 40 0 20 % N
% Pro: 0 0 0 0 10 0 10 0 20 0 10 10 20 0 0 % P
% Gln: 0 0 0 0 30 10 0 0 0 0 0 0 0 0 0 % Q
% Arg: 10 0 0 0 30 0 0 0 10 0 10 0 0 0 0 % R
% Ser: 10 0 10 20 10 40 30 0 20 0 0 20 0 20 30 % S
% Thr: 0 0 0 20 0 20 0 10 10 0 10 10 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 10 0 0 10 0 0 % V
% Trp: 0 10 40 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 20 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _